The relationship between knowledge and visual forms has changed as tools and platforms used for data display, discovery, and modeling have become ubiquitous. These practices raise basic questions about the nature of visual epistemology—whether it is a primary, secondary, or tertiary form of knowledge. This talk addresses some of the ways these practices and the assumptions on which they are based raise concerns for work in the humanities, broadly considered. Current projects in computational and digital scholarship form one set of focus points for this talk, but the argument stresses conceptual continuities between analog and digital practices in order to call attention to the particular features of computational work in information visualization. At stake are questions of cultural authority and the politics of representation as well as issues in the status of visuality as they relate to future research.